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Results 1 - 10 of 132 > >>
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EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.2more inactivated by the serine/threonine phosphatase 2A but not by the protein-tyrosine phosphatase 1B Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.2more occludin acts as antagonist of the MEK and ERK signaling pathway inducing cell aggregation of pancreatic cancer cells Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.2more treatment with LY294002, paclitaxel, or serum starvation does not induce apoptosis of wild-type MEF cells Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.2more design and synthesis of 4-anilino-5-carboxamido-2-pyridone MEK1 inhibitors using a combination of medicinal chemistry, computational chemistry, and structural elucidation, overview. Binding structure analysis, overview Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.2more no MEK inhibition by theobromine Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.2more MEK, p38, and IKK inhibitors block TNF-alpha-induced IL-8, IL-6, and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.2more stress-induced target of rapamycin complex 1 activation can be blocked by RNAi against mitogen-activated protein kinase kinase 3 and 6 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.2more known inhibitor structure screening, and design of specific allosteric MEK1/2 inhibitors with improved pharmacokinetic/pharmacodynamic profiles to be used as alternative cancer medications. Trametinib is used as the lead structure. Molecular docking and binding simulations, thermodynamics, and quantitative structure-activity relationships, allosteric inhibitory site, overview Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.2more the MEK enzyme contains a hydrophobic allosteric pocket adjacent to the ATP-binding site which allows for the design of highly selective allosteric inhibitors Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.2more design of small molecule MEK1/2 inhibitors to block ERK1/2-mediated signaling and inhibit proliferation. Four structurally distinct MEK1/2 inhibitors acutely affect mitochondrial bioenergetics. The anti-mitochondrial effects of MEK1/2 inhibitors determine the proliferative potential; design of small molecule MEK1/2 inhibitors to block ERK1/2-mediated signaling and inhibit proliferation. Four structurally distinct MEK1/2 inhibitors acutely affect mitochondrial bioenergetics. The anti-mitochondrial effects of MEK1/2 inhibitors determine the proliferative potential Go to the Ligand Summary Page
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