EC Number   |
Inhibitors |
Structure |
|---|
   2.7.1.227 | (1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-(2-propylpentanoyl)valinate |
synthetic inhibitor based on aureobasdidin A structure, reversible |
   |
| 2.7.1.227 | (1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-(6-phenylhexanoyl)valinate |
synthetic inhibitor based on aureobasdidin A structure, reversible |
|
| 2.7.1.227 | (1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-nonanoylvalinate |
synthetic inhibitor based on aureobasdidin A structure, reversible |
|
| 2.7.1.227 | (2R,4E)-2-aminooctadec-4-en-1-ol |
compound displays significant anti-protozoal effects at the concentrations analyzed |
|
| 2.7.1.227 | 1-phosphatidyl-1D-myo-inositol |
substrate inhibition |
|
| 2.7.1.227 | 3-(1,3-benzodioxol-5-yl)-6-[[(1E)-1H-pyrrol-2-ylmethylene]amino]-2H-chromene-2-one |
coumarin derivative. Molecular dynamics modeling, free energy of binding is -9.5 kcal/mol |
|
| 2.7.1.227 | 3-(2H-1,3-benzodioxol-5-yl)-6-[(E)-[(furan-2-yl)methylidene]amino]-2H-1-benzopyran-2-one |
coumarin derivative with little cytotoxic effects.Molecular dynamics modeling, free energy of binding is -9.8 kcal/mol |
|
| 2.7.1.227 | 3-[(4-fluorophenyl)methyl]-7-(1H-pyrrole-1-sulfonyl)-2,3,4,5-tetrahydro-1H-3-benzazepine |
selective, non-toxic benzazepane inhibitor, inhibits the enzyme at nanomolar concentrations |
|
| 2.7.1.227 | 4-(2,5-dimethyl-4-[(E)-[(piperidin-1-yl)methylidene]amino]phenoxy)-2-(2,2-dimethylpropyl)benzonitrile |
inhibitor shows selectivity for isoform IPCS2 over the yeast orthologue, and activity against Arabidopsis thaliana seedlings |
|
| 2.7.1.227 | 7-(4-fluoro-1H-indole-1-sulfonyl)-3-[(pyridin-3-yl)methyl]-2,3,4,5-tetrahydro-1H-3-benzazepine |
selective, non-toxic benzazepane inhibitor, inhibits the enzyme at nanomolar concentrations |
|
