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Results 1 - 10 of 185 > >>
EC Number
Inhibitors
Commentary
Structure
(+/-)-(1S,2R,4S,5S)-4-amino-6,6-difluorobicyclo[3.1.0]hexane-2-carboxylic acid
10 mM, weak, reversible inhibitor
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(+/-)-(1S,2S,4S,5S)-4-amino-6,6-difluorobicyclo[3.1.0]hexane-2-carboxylic acid
10 mM, weak, reversible inhibitor
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(+/-)piperidine-3-sulfonic acid
-
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(1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid
mechanism-based inactivation, adduct formed is derived from enamine mechanism
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(1R,4S)-4-amino-2-cyclopentene-1-carboxylic acid
analogue of 4-aminobutanoate, vigabatrin
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(1R,4S)-4-amino-3-fluorocyclopent-2-enecarboxylic acid
weak reversible inhibition in the presence of beta-mercaptoethanol
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(1R,4S)-4-amino-3-pentafluoroethylcyclopent-2-enecarboxylic acid
weak reversible inhibition in the presence of beta-mercaptoethanol
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(1R,4S)-4-amino-3-trifluoromethylcyclopent-2-enecarboxylic acid
irreversible inhibition in the presence of beta-mercaptoethanol
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(1S,2S,3E)-2-amino-3-(fluoromethylidene)cyclopentanecarboxylic acid
monofluorinated analog of inhibitor CPP-115. Compound produces a metabolite that induces disruption of the Glu270-Arg445 salt bridge of GABA transaminase to accommodate interaction between the metabolite formyl group and Arg445. The inactivation mechanism is initiated by Schiff base formation with the active site pyridoxal 5'-phosphate, followed by gamma-proton removal
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(1S,2S,3Z)-2-amino-3-(fluoromethylidene)cyclopentanecarboxylic acid
monofluorinated analog of inhibitor CPP-115. Compound produces a metabolite that induces disruption of the Glu270-Arg445 salt bridge of GABA transaminase to accommodate interaction between the metabolite formyl group and Arg445. The inactivation mechanism is initiated by Schiff base formation with the active site pyridoxal 5'-phosphate, followed by gamma-proton removal
Go to the Ligand Summary Page
Results 1 - 10 of 185 > >>