EC Number |
Inhibitors |
Structure |
---|
2.6.1.16 | more |
no inhibition by 0.1 mM c3, 4, 6, 9, 12, 13 |
|
2.6.1.16 | more |
a series of covalent cholesterol-spiro pyrrolidine/pyrrolizidine heterocyclic hybrids possessing biologically active oxindole, indanedione, and acenaphthylene-1-one are synthesized as enzyme inhibitors by the reaction of C3-beta-cholesteroalacrylate with heterocyclic di- and tri-ketones, the compounds are obtained as a single isomer in good yield through a stereo- and regioselective 1,3-dipolar cycloaddition methodology, method overview. Analysis of in vitro antibacterial activity, and inhibitory activity against highly pathogenic Gram-positive and Gram-negative bacteria. Automated in silico molecular docking analysis of cadidates in order to validate their effective orientation as inhibitors bound in the active site of glucosamine-6-phosphate synthase (1XFF) enzyme |
|
2.6.1.16 | more |
synthesis of naringenin derivatives with potent glucosamine-6-phosphate synthase inhibitory capacities and antioxidant, antimicrobial, and preservative efficacy. Molecular docking and in silico ADMET analysis, structure-activity relationship studies, overview. MIC values for growth inhibition of the cells |
|
2.6.1.16 | p-chloromercuribenzoate |
- |
|
2.6.1.16 | p-chloromercuribenzoate |
84% inhibition at 0.1 mM |
|
2.6.1.16 | N-ethylmaleimide |
irreversible inhibition |
|
2.6.1.16 | N-ethylmaleimide |
78% inhibition at1 mM |
|
2.6.1.16 | UDP-glucose |
- |
|
2.6.1.16 | iodoacetamide |
irreversible inhibition |
|
2.6.1.16 | iodoacetamide |
- |
|