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Results 1 - 10 of 11 > >>
EC Number
Inhibitors
Commentary
Structure
(2R,3R,4R,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl hydrogen ((E)-((3R,4R,5S)-5-((R)-1,2-dihydroxyethyl)-3,4-dihydroxydihydrofuran-2(3H)-ylidene)fluoromethyl)phosphonate
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(2R,3R,4R,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl hydrogen ((Z)-((3R,4R,5S)-5-((R)-1,2-dihydroxyethyl)-3,4-dihydroxydihydrofuran-2(3H)-ylidene)fluoromethyl)phosphonate
-
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(3S,4S)-3-(1,2-dihydroxyethyl)-4-hydroxy-1-(2-phenylethyl)tetrahydrothiophenium chloride
sulfonium ion compound as analogue of the donor substrate, uridine diphosphategalactofuranose. The compound contains moieties that mimic both galactofuranose and uridine diphosphate domains, and carries a permanent positive charge to mimic the oxocarbenium ion-like transition state. About 60% inhibition at 4 mM
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(3S,4S)-3-(1,2-dihydroxyethyl)-4-hydroxy-1-[2-(4-nitrophenyl)ethyl]tetrahydrothiophenium bromide
sulfonium ion compound as analogue of the donor substrate, uridine diphosphategalactofuranose. The compound contains moieties that mimic both galactofuranose and uridine diphosphate domains, and carries a permanent positive charge to mimic the oxocarbenium ion-like transition state. About 50% inhibition at 4 mM
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EDTA
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more
not inhibited by UDP-2''-O-methyl-alpha-D-galactofuranose
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UDP-3''-deoxy-alpha-D-xylo-hexofuranose
68% inhibition at 1.25 mM
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UDP-5''-O-methyl-alpha-D-galactofuranose
15% inhibition at 1.25 mM
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UDP-5-deoxy-alpha-D-galactofuranose
10% inhibition at 1.25 mM
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UDP-6''-O-methyl-alpha-D-galactofuranose
26% inhibition at 1.25 mM
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Results 1 - 10 of 11 > >>