EC Number   |
Inhibitors |
Structure  |
|---|
  2.3.1.301 | more |
2-tosylnaphthalene-1,4-diol analogues are reversible inhibitors (30 nM-5 microM) of the Mycobacterium tuberculosis and Plasmodium falciparum FabH enzymes. The sulfonyl group and naphthalene-1,4 diol are required for activity against all enzymes but the toluene portion can be significantly altered. Inhibitors are also effective against Escherichia coli FabH, EC 2.3.1.180 |
 |
| 2.3.1.301 | more |
not inhibitory: cerulenin |
|
| 2.3.1.301 | thiolactomycin |
- |
  |
| 2.3.1.301 | 1-(1-bromoheptyl)-4-(4-[[(2,4-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid |
compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks |
|
| 2.3.1.301 | 1-(1-bromohexyl)-4-(4-[[(3,5-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid |
compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks |
|
| 2.3.1.301 | 1-(1-bromooctyl)-4-(4-[[(2,5-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid |
compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks |
|
| 2.3.1.301 | 1-(3-carboxypropyl)-4-[4-[(3,5-difluorophenyl)methoxy]phenyl]-1H-pyrrole-2-carboxylic acid |
compound possesses good in vitro antimycobacterial activity, MIC value 12.5 microg/ml |
|
| 2.3.1.301 | 1-([[(2-hydroxyethyl)disulfanyl]carbonyl]oxy)octane |
- |
|
| 2.3.1.301 | 1-[(3-chlorophenyl)methyl]-4-(4-[[(2,4-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid |
compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks |
|
| 2.3.1.301 | 1-[(4-chlorophenyl)methyl]-4-(4-[[(2,4-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid |
compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks |
|
