EC Number |
Inhibitors |
Structure |
---|
2.3.1.12 | 1,2-diselenolane-3-valeric acid |
competitive with respect to dihydrolipoamide and non-competitive with respect to acetyl-CoA |
|
2.3.1.12 | CoA |
competitive to acetyl-CoA, non-competitive to dihydrolipoamide |
|
2.3.1.12 | guanidine hydrochloride |
50% inhibition at 0.3 M, complete inhibition at 0.7-1 M |
|
2.3.1.12 | Iodine |
complete inactivation at 2.5 mol iodine per mol of subunit |
|
2.3.1.12 | lipoamidase |
complete loss of activity after 3 h |
|
2.3.1.12 | more |
starvation inhibits the overall complex reaction |
|
2.3.1.12 | N-Acetylimidazole |
modifies tyrosyl residues and dissociates the enzyme into subunits |
|
2.3.1.12 | palmitoyl-CoA |
competitive to acetyl-CoA, non-competitive to dihydrolipoamide |
|
2.3.1.12 | S-acetyldihydrolipoamide |
competitive to dihydrolipoamide, non-competitive to acetyl-CoA |
|