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Results 1 - 9 of 9
EC Number
Inhibitors
Commentary
Structure
1,2-diselenolane-3-valeric acid
competitive with respect to dihydrolipoamide and non-competitive with respect to acetyl-CoA
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CoA
competitive to acetyl-CoA, non-competitive to dihydrolipoamide
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guanidine hydrochloride
50% inhibition at 0.3 M, complete inhibition at 0.7-1 M
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Iodine
complete inactivation at 2.5 mol iodine per mol of subunit
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lipoamidase
complete loss of activity after 3 h
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more
starvation inhibits the overall complex reaction
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N-Acetylimidazole
modifies tyrosyl residues and dissociates the enzyme into subunits
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palmitoyl-CoA
competitive to acetyl-CoA, non-competitive to dihydrolipoamide
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S-acetyldihydrolipoamide
competitive to dihydrolipoamide, non-competitive to acetyl-CoA
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Results 1 - 9 of 9