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Results 1 - 10 of 26 > >>
EC Number
Inhibitors
Commentary
Structure
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no enzyme inhibibtion by atpenin A5, an inhibitor of Complex II
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pyruvate
-
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acetate
competitive
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succinate
uncompetitive inhibitor, in the presence of low levels of proline in vivo, higher levels of succinate can act to inhibit PRODH/POX activity and reactive oxygena species generation. The affinity of succinate is for the enzyme-substrate complex of PRODH/POX and proline rather than for the enzyme binding site for proline. Succinate protects electron transport chain component proteins from PRODH/POX reactive oxygen species-mediated downregulation with almost the same efficacy as 3,4-dehydro-L-proline and N-acetyl-L-cysteine
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cyanide
only membrane-associated enzyme, not soluble enzyme
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KCN
very strong inhibition
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L-proline
substrate inhibition at high L-proline concentrations; substrate inhibition at high L-proline concentrations
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L-proline
substrate inhibition at high L-proline concentrations
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L-lactate
-
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L-lactate
competitive
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Results 1 - 10 of 26 > >>