EC Number   |
Inhibitors |
Structure  |
|---|
    1.1.1.22 | more |
no substrate inhibition, K+ is not inhibitory up to 500 mM, not inhibitory: dimethyldicarbonate, EDTA |
 |
| 1.1.1.22 | more |
in the presence of 0.12 mM 5-azido-UDP-glucose, 89% of the enzyme activity is lost after 5 min of photolabeling. When the enzyme is photolyzed in presence of 1 mM UDP-glucose, 11% of the enzyme activity is lost. 5-azido-UDP-glucose is photoinserting into a UDP-glucose-binding site on the human enzyme in a specific manner. Uracil, uridine, and glucose have a poor protective effect on the labeling, while UDP and UDP-glucose strongly inhibit photoinsertion |
|
| 1.1.1.22 | more |
inhibition of human UDP-glucose dehydrogenase expression using siRNA expression vector in breast cancer cells |
|
| 1.1.1.22 | more |
the enzyme from serotype K30 is not inhibited by NAD+, in contrast to Escherichia coli K-12 |
|
| 1.1.1.22 | more |
enzyme is active in the absence of metal ions |
|
| 1.1.1.22 | NAD+ |
substrate inhibition, reversible by the addition of a nucleotide triphosphate, e.g. ATP, in the absence of kinase. Mutations in a previously identified UDP-glucuronic acid allosteric binding site decrease the binding affinity of the nucleotide triphosphate |
  |
| 1.1.1.22 | NADH |
- |
|
| 1.1.1.22 | NADH |
0.1 mM, presence of 0.1 mM NAD+, 44% inhibition, presence of 0.5 mM NAD+, 6% inhibition |
|
| 1.1.1.22 | NADH |
product inhibition, 26% residual activity at 0.05 mM; product inhibition, 70% residual activity at 0.05 mM |
|
| 1.1.1.22 | NADH |
0.05 mM, partial inhibition |
|
