EC Number   |
Inhibitors |
Structure |
|---|
   6.5.1.2 | N4-(7-chloro-7,8-dihydroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine |
- |
   |
| 6.5.1.2 | N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentame-1,4-diamine |
- |
|
| 6.5.1.2 | Na+ |
above 20-150 mM |
|
| 6.5.1.2 | NAD+ |
inhibitory above 0.1 mM, activity is abolished at 0.5 mM |
|
| 6.5.1.2 | nicotinamide mononucleotide |
- |
|
| 6.5.1.2 | pinafide |
i.e. 3-nitro-N-(2-(1-pyrrolidinyl)ethyl)-1,8-naphthalimide |
|
| 6.5.1.2 | putrescine |
- |
|
| 6.5.1.2 | pyridochromanone |
IC50: 0.0006 mM |
|
| 6.5.1.2 | pyridochromanones |
differently substituted compounds tested and all found to be inhibitory, competitive with NAD+, inhibitory in nano-molar rage without affecting human DNA-ligase (ATP-depentend) activity |
|
| 6.5.1.2 | Quinacrine |
powerful inhibitor, exhibits good inhibition at nanomolar concentrations |
|
