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EC Number
Inhibitors
Commentary
Structure
4.1.1.11
acetyl-CoA
CoA-dependent interaction of PanZ and PanD. Growth inhibition is due to the CoA-dependent PanD-PanZ interaction and the inhibition occurs at native concentrations of PanD and PanZ in the cell. The production of beta-alanine is feedback-regulated by the PanZ-AcCoA complex
4.1.1.11
beta-hydroxy-DL-Asp
-
4.1.1.11
CoA
the CoA-dependent interaction inhibits catalysis by the activated enzyme. Binding of acetyl-CoA to PanZ is required to form the PanZ/PanD interface. PanZ.AcCoA inhibits the activated enzyme regulating pantothenate biosynthesis. The binding site for AcCoA is very close to the protein-protein interface. Structure of the complex of PanD and its activating factor PanZ with bound CoA, overview
4.1.1.11
CuCl
10 mM, 88% inhibition
4.1.1.11
D-Ser
-
4.1.1.11
D-tagatose
ZINC03830878, weak inhibition
4.1.1.11
D-Tartrate
ZINC00895296, strong inhibition
4.1.1.11
DL-threo-beta-hydroxyaspartate
strong inhibition
4.1.1.11
hydroxylamine
-
4.1.1.11
KCl
200 mM, 63% inhibition
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