EC Number   |
Inhibitors |
Structure |
|---|
   3.4.21.7 | 4-amidinophenyl methane-sulfonyl fluoride |
substantially abrogates the relaxing effect of plasmin. Abolishes plasmin-induced Ca2+ elevation by its pretreatment of plasmin |
   |
| 3.4.21.7 | 4-aminobenzamidine |
competitive inhibition |
|
| 3.4.21.7 | 4-aminomethylbenzamidine |
competitive inhibition |
|
| 3.4.21.7 | 4-carboxybenzamidine |
competitive inhibition |
|
| 3.4.21.7 | 479-504 peptide of factor VIII |
blocks A2 subunit binding to Ah-plasmin by ca. 50% in a dose-dependent manner |
|
| 3.4.21.7 | 484-509 peptide of factor VIII |
blocks A2 subunit binding to Ah-plasmin by ca. 50% in a dose-dependent manner |
|
| 3.4.21.7 | 489-514 peptide of factor VIII |
weakly inhibits binding of the A2 subunit and plasmin with ca. 80% residual binding at the highest concentration (0.8 mM) of peptide |
|
| 3.4.21.7 | 5,5'-(butane-1,4-diylbis(oxy))bis(2-(3,4-O,O-disulfonato-phenyl)-3,7-O,O-disulfonato-4H-chromen-4-one |
about 42% residual activity at 0.4 mM |
|
| 3.4.21.7 | 6-aminohexanoate |
- |
|
| 3.4.21.7 | 6-aminohexanoic acid |
blocks the interactions between light chain and plasmin in a dose-dependent manner by more than 90%. Blocks A2 subunit and plasmin interaction weakly by ca. 30%. Inhibitory effect of 6-aminohexanoic acid on the interaction between the heavy chain or factor VIII and Ah-plasmin is similar to that for the A2 interaction |
|
