EC Number |
Inhibitors |
Structure |
---|
3.4.21.47 | factor H |
the inhibitor blocks both C3 and C5 conversion |
|
3.4.21.47 | factor H related-protein 5 |
inhibits C5 conversion in a concentration-dependent manner |
|
3.4.21.47 | hemocyanin-depleted plasma |
preincubation of hemocyanin-depleted plasma with the anti-factor C Ab (2B7) dose-dependently inhibits the proteolytic conversion of C3 to C3b in the presence of LPS |
|
3.4.21.47 | hydroxylamine |
inactivates the thioester bond on C3, dramatically decreases the deposition of C3b on microbes |
|
3.4.21.47 | Leu-Gly-Leu-Ala-Arg-sarcosine |
inhibits C5 cleavage |
|
3.4.21.47 | more |
the anticoagulogen Ab (14E7) has no effect on the conversion of C3. Abs against coagulation factor G (monoclonal) and the proclotting enzyme (polyclonal) do not inhibit the deposition of C3b on Escherichia coli |
|
3.4.21.47 | more |
eculizumab does not block the activity of the APC C3 convertase |
|
3.4.21.47 | more |
the anti-factor B autoantibody binds to factor B and to the alternative pathway C3 convertase and alters the kinetics of complement activation and regulation, the anti-factor B autoantibody does not influence the assembly of the C3 convertase |
|
3.4.21.47 | more |
addition of guinea pig serum in 40 mM EDTA initiates lysis of existing convertase complexes and excludes the possibility of de novo convertase formation |
|
3.4.21.47 | more |
regulatory proteins inactivate C3/C5 convertases on host surfaces to avoid collateral tissue damage |
|