EC Number   |
Inhibitors |
Structure |
|---|
    2.6.1.16 | methylglyoxal |
50% inhibition at 0.01 mM, non competitive |
   |
| 2.6.1.16 | methylglyoxal |
inhibits preincubated enzyme less profoundly than the untreated enzyme |
|
| 2.6.1.16 | more |
no inhibition by 0.1 mM c3, 4, 6, 9, 12, 13 |
|
| 2.6.1.16 | more |
a series of covalent cholesterol-spiro pyrrolidine/pyrrolizidine heterocyclic hybrids possessing biologically active oxindole, indanedione, and acenaphthylene-1-one are synthesized as enzyme inhibitors by the reaction of C3-beta-cholesteroalacrylate with heterocyclic di- and tri-ketones, the compounds are obtained as a single isomer in good yield through a stereo- and regioselective 1,3-dipolar cycloaddition methodology, method overview. Analysis of in vitro antibacterial activity, and inhibitory activity against highly pathogenic Gram-positive and Gram-negative bacteria. Automated in silico molecular docking analysis of cadidates in order to validate their effective orientation as inhibitors bound in the active site of glucosamine-6-phosphate synthase (1XFF) enzyme |
|
| 2.6.1.16 | more |
synthesis of naringenin derivatives with potent glucosamine-6-phosphate synthase inhibitory capacities and antioxidant, antimicrobial, and preservative efficacy. Molecular docking and in silico ADMET analysis, structure-activity relationship studies, overview. MIC values for growth inhibition of the cells |
|
| 2.6.1.16 | N-acetyl-2-amino-2-deoxy-D-glucitol-6-phosphate |
- |
|
| 2.6.1.16 | N-ethylmaleimide |
irreversible inhibition |
|
| 2.6.1.16 | N-ethylmaleimide |
78% inhibition at1 mM |
|
| 2.6.1.16 | N-iodoacetylglucosamine 6-phosphate |
D-fructose 6-phosphate protects |
|
| 2.6.1.16 | N3-(4-Methoxyfumaroyl)-L-2,3-diaminopropanoic acid |
L-glutamine and some analogs protect |
|
