EC Number |
Inhibitors |
Structure |
---|
1.4.4.2 | KCl |
inhibition of glycine-CO2 exchange reaction |
|
1.4.4.2 | Modified H-protein |
lipoic acid prosthetic group and cysteinyl residues modified with N-ethylmaleimide |
|
1.4.4.2 | more |
inhibitors of the multienzyme complex |
|
1.4.4.2 | more |
inactivation after incubation with glycine in presence of aminomethyl carrier protein (H-protein), it is a suicide reaction of the P-protein as a side reaction of the glycine decarboxylation |
|
1.4.4.2 | more |
low CO2 concentrations decrease expression of GDC |
|
1.4.4.2 | N-ethylmaleimide |
- |
|
1.4.4.2 | N-ethylmaleimide |
complete inhibition |
|
1.4.4.2 | N4-methylglutamine |
inhibition of glycine-CO2 exchange reaction |
|
1.4.4.2 | Ni2+ |
inhibition of glycine-CO2 exchange by binding of metal with H-protein-bound intermediate of glycine decarboxylation |
|
1.4.4.2 | S-nitrosoglutathione |
i.e. GSNO, the glycine decarboxylase complex, GDC activity is inhibited by S-nitrosoglutathione due to S-nitrosylation/S-glutathionylation of several cysteine residues, overview. The inhibition of GDC activity after GSNO treatment can be an indirect effect of ROS induced by inhibition of complex I |
|