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EC Number
Inhibitors
Commentary
Structure
5.4.3.8
gabaculine
0.0005 mM, 50% inhibition. The inhibition is reversible up to 1 h after its addition, if the gabaculine is removed by gel filtration, before the enzyme is incubated by gel filtration, before the enzyme is incubated with substrate. Irreversible inhibition is obtained by preincubation of the enzyme at 30°C either for several hours with gabaculine alone or for a few min with both gabaculine and glutamate-1-semialdehyde
5.4.3.8
gabaculine
-
5.4.3.8
gabaculine
wild-type enzyme is inhibited, gabaculine-resistant mutant enzyme is not inhibited
5.4.3.8
gabaculine
potent inhibitor
5.4.3.8
D-penicillamine
20 mM, 9% inhibition
5.4.3.8
cycloserine
20 mM, 43% inhibition
5.4.3.8
4,5-Dioxovalerate
competitive inhibition of pyridoxamine-phosphate form of the enzyme and mixed-type inhibition of the pyridoxal-phosphate form of the enzyme
5.4.3.8
4-Amino-5-hexynoic acid
-
5.4.3.8
4-Amino-5-fluoro-pentanoic acid
-
5.4.3.8
4-Amino-5-hexenoic acid
-
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