EC Number   |
Inhibitors |
Structure |
|---|
   3.4.21.7 | D-Val-Phe-Lys-chloromethyl ketone |
inhibits the ability of plasmin to potentiate lipopolysaccharide signalling. Significantly inhibits the generation of TNFalpha from untransfected RAW cells after plasmin pretreatment and stimulated with LPS |
   |
| 3.4.21.7 | discreplasminin |
isolated from Tityus discrepans scorpion venom. Peptide with a relative molecular weight of less than 6000 Da and a pI value of 8.0. Discreplasminin strongly inhibits plasmin and moderately inhibits tissue plasminogen activator |
|
| 3.4.21.7 | AG490 |
JAK inhibitor, inhibits JAK1 but does not inhibit TYK2 phosphorylation by plasmin. Impairs plasmin-mediated phosphorylation of ERK1/2, Akt1, and the subsequent phosphorylation of IkappaBalpha, but not that of p38 MAPK. Inhibits plasmin-induced TNF-alpha release by 63% and IL-6 release by 76% |
|
| 3.4.21.7 | alpha2-antiplasmin |
kinetics of plasmin type 1 and 2 inhibition in absence of soluble fibrin or epsilon-caproic acid is a reversible slow binding inhibition with an initial loose complex and a following tight complex. Epsilon-amino-caproic acid slows down the first step of the reaction without effect on the second step. Fibrin slows down both reaction steps |
|
| 3.4.21.7 | alpha2-Plasmin inhibitor |
kringle domains K2, K3, and K5 are involved in the modulation of Plm activity |
|
| 3.4.21.7 | more |
L-methionine and L-alanine show minimal reductions of enzyme activity, even at 125 mM |
|
| 3.4.21.7 | neuroserpin |
mainly expressed in the brain, a serpin and single-chain glycoprotein of 55 kDa containing three potential N-glycosylation sites at Asn141, Asn305, and Asn385 |
|
| 3.4.21.7 | PD98059 |
MEK inhibitor, completely abolishes plasmin-induced phosphorylation of ERK1/2 at 0.05 mM |
|
| 3.4.21.7 | N-[(1S)-5-amino-1-cyanopentyl]-3-([3-[1-(4-fluorobenzyl)-1H-indol-3-yl]propanoyl]amino)-4-(pyridin-4-ylmethoxy)benzamide |
molecular modeling |
|
| 3.4.21.7 | cis-parinaric acid |
more than 60% inhibition of pro-matrix metalloproteinase-3 activation at 0.05 mM |
|
