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EC Number
Inhibitors
Commentary
Structure
N-propargylglycine
irreversibly inactivates PutA by covalently linking the flavin N(5) atom to the epsilon-amino of Lys329. Inactivation locks PutA into a conformation that may mimic the proline-reduced, membrane-associated form
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pyrrolidone-5-carboxylate
;
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pyrrolidone-5-carboxylate
-
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pyruvate
-
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rotenone
an inhibitor of Complex I, addition of ROT only modestly affects PRODH/POX activity
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succinate
uncompetitive inhibitor, in the presence of low levels of proline in vivo, higher levels of succinate can act to inhibit PRODH/POX activity and reactive oxygena species generation. The affinity of succinate is for the enzyme-substrate complex of PRODH/POX and proline rather than for the enzyme binding site for proline. Succinate protects electron transport chain component proteins from PRODH/POX reactive oxygen species-mediated downregulation with almost the same efficacy as 3,4-dehydro-L-proline and N-acetyl-L-cysteine
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