   2.4.1.255 | protein O-GlcNAc transferase |
N-terminally truncated construct starting at amino acid 353 in tetratricopeptide repeat TPR 10 (D135), crystallized in complex with the inhibitor/substrate analogue UDP-5S-GlcNAc, to 2.7 A resolution. The enzyme adopts the canonical OGT fold with the bilobal arrangement of two Rossmann-like domains, as well as the additional TPR-like helices (535566) in the N-terminal of the catalytic domain. As a result, the TPRs are in close association with the glycosyltransferase domain and the catalytic site is aligned with the channel along the main axis of the TPR superhelix |
Drosophila melanogaster |
Q7KJA9 |
736927 |
