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General Stability
Reference
3.4.24.75
lysostaphin degrades Staphylococcus aureus cell walls inefficiently in low conductivity buffers (10-50 mS/cm)
733579
3.4.24.75
lysostaphin fused it with an anti-parallel alpha-helical dimerization domain has a more favorable pharmacokinetic profile with increased terminal half-life compared to monomeric lysostaphin. However, the staphylolytic activity of dimerized lysostaphin is decreased.
754802
3.4.24.75
lysostaphin is relatively stable when conjugated with polyethylene glycol and it maintains its activity in human serum
720624
3.4.24.75
relatively unaffected by salt concentrations between 200 and 500 mM, LysK has a higher specific activity than lysostaphin at NaCl concentrations higher than 150 mM (turbidity reduction assay)
697979
3.4.24.75
trypsin inactivates
31510
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