EC Number   |
Activating Compound |
Reference |
|---|
    5.1.2.1 | LacR |
hypothetical model of PlarA regulation by LarR: in the presence of L-lactate, activated LarR binds to the Lar box motif and multimerizes on the half-Lar boxes. This will promote direct interaction of one LarR dimer with the RNA polymerase, resulting in transcriptional activation of the PlarA (productive binding). In the presence of D-lactate, D-lactatet can block LarR activation, for instance, by impairing L-lactate recognition, which will result in limited LarR binding and multimerization and absence of transcriptional activation (unproductive binding) |
748098 |
| 5.1.2.1 | more |
lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system. Effect of accessory Lar proteins and cofactors on the in vitro activation of LarANiDELTABCE (apo-LarA) by LarENiBC, overview. Necessity of the Lar accessory proteins (larBCE), for LarA activation. Ni-loaded LarE acts as a maturation protein responsible for the activation of apo-LarA, and indicate that LarB and LarC are involved in the activation of LarE prior to apo-LarA activation |
745850 |
| 5.1.2.1 | more |
nickel-binding site structure and the role of three accessory proteins required for its activation, overview |
749373 |
| 5.1.2.1 | more |
the lactate racemase is a nickel-dependent enzyme requiring activation by the accessory protein LarE, which itself requires activation by the accessory proteins LarB and LarC and nickel |
748098 |
| 5.1.2.1 | more |
yeast extract (0.1% (w/v)), MgSO4 (2 mM), MnSO4 (2 mM) and ascorbic acid (2 mM) enhance lactate racemase activity in vitro |
662040 |
