EC Number   |
Activating Compound |
Reference |
|---|
   3.6.5.2 | ACAP3 |
aGTPase-activating protein (GAP) specific to small GTPase Arf6. ACAP3 is involved in neuronal migration in the developing cerebral cortex of mice, regulation mechanism, detailed overview. ACAP3 is abundantly expressed in the developing cerebral cortex. GAP activity of ACAP3 is required for neuronal migration. Knockdown of ACAP3 in the developing cortical neurons of mice in utero significantly abrogates neuronal migration in the cortical layer, which is restored by ectopic expression of wild-type ACAP3, but not by its GAP-inactive mutant |
755959 |
| 3.6.5.2 | alphabeta-tubulin |
soluble alphabeta-tubulin acts as a constitutively active Rheb activator that performs direct Rheb-binding, the deacetylated form has a high binding affinity for Rheb. Deacetylated soluble tubulin has a positive role in Rheb function by increasing the GTP-bound Rheb levels. Overexpression of alpha-tubulin K40A increases Rheb-induced S6K1 phosphorylation |
733638 |
| 3.6.5.2 | angiotensin II |
stimulates Rac1 as cardiovascular stimulus |
734348 |
| 3.6.5.2 | C3G guanine nucleotide exchange factor |
- |
720356 |
| 3.6.5.2 | Calcium |
- |
720356 |
| 3.6.5.2 | CalDAG-GEF |
a guanine nucleotide exchange factor |
720356 |
| 3.6.5.2 | cAMP |
- |
720356 |
| 3.6.5.2 | CAPRI |
a member of the GAP1 family of GTPase-activating proteins, GAPs, for small G proteins functioning as an amplitude sensor for intracellular Ca2+ levels stimulated by extracellular signals. It has a catalytic domain with dual Ras-GAP and RapGAP activities, and acts as dimer and monomer. CAPRI switches between its two GAP activities, RasGAP and Rap1GAP, mechanism, overview. Structure and activity of the C-terminal tail of Mus musclus CAPRI, activities on endogenous Rap1 in vivo of the recombinant full-length and C-terminal part of murine CAPRI in CHO cells, overview. Wild-type and monomeric CAPRI translocate to the plasma membrane similarly, but monomers are stronger RasGAPs at the membrane level |
719932 |
| 3.6.5.2 | Cdc42 |
activation of Rac |
644119 |
| 3.6.5.2 | cytotoxic necrotizing factor 1 |
activation of Rho proteins by the cytotoxic necrotizing factor 1 (CNF1) from Escherichia coli, while the isomeric cytotoxicnecrotizing factor from Yersinia pseudotuberculosis (CNFy) drives GTP-loading of basal RhoB but fails to cause activation of the rhoB promoter and thus its expression. CNF1 inhibits cytokinesis and induces the formation of bi-nucleated (tetraploid) cells. Cytotoxic-necrotizing factors encompass a class of auto-transporter toxins produced by Escherichia coli (CNF1-3) or Yersinia pseudotuberculosis (CNFy). CNF1 specifically deamidates RhoA. CNF1-induced RhoB response depends on the deamidation of Rho proteins |
733982 |
