EC Number   |
Activating Compound |
Reference |
|---|
    3.5.4.12 | (4Z,7Z,10Z,13Z,16Z,19Z)-henicosa-4,7,10,13,16,19-hexaenoic acid |
increases the enzyme activity in vivo in normal Rat-2 fibroblasts, but decreases it in transformed NM-16 fibroblasts |
667541 |
| 3.5.4.12 | 1-beta-D-arabinofuranosylcytosine 5'-triphosphate |
low activation, allosteric activator |
288999 |
| 3.5.4.12 | 2-mercaptoethanol |
enzyme requires dCTP, Zn2+, and 2-mercaptoethanol |
289005 |
| 3.5.4.12 | 3,4,5,6-tetrahydro-2'-dUMP |
high-affinity inhibitor, rapid, reversible inhibition, kinetics of inhibition. At low substrate or competitor concentrations: activation. Tetrahydro-dUMP activates enzyme at low substrate concentrations |
289014 |
| 3.5.4.12 | 5-hydroxymethyl-dCTP |
- |
289004 |
| 3.5.4.12 | 5-hydroxymethyl-dCTP |
30% activation |
289011 |
| 3.5.4.12 | 5-hydroxymethyl-dCTP |
natural activator, required for activity |
289015 |
| 3.5.4.12 | 5-hydroxymethyl-dCTP |
natural positive allosteric effector, enzyme is much more effectively regulated by its natural effector, 5-hydroxymethyl-dCTP, than by dCTP, binding of 5-hydroxymethyl-dCTP is much more pH dependent than dCTP |
288997, 289009, 289010, 289015, 289017 |
| 3.5.4.12 | 5-hydroxymethyl-dCTP |
pH-dependent activation |
289009, 289010 |
| 3.5.4.12 | ammonium sulfate |
substrate dCMP-Hg-S-CH2-CH2-OH, 0.2 M ammonium sulfate: activation, reversed by cCTP |
289003 |
