EC Number   |
Activating Compound |
Reference |
|---|
   3.4.24.86 | 12-HPETE |
i.e. 12-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid, a peroxide synthesized in the platelet lipoxygenase pathway, induces TACE-mediated receptor cleavage |
711689 |
| 3.4.24.86 | angiotensin II |
treatment with angiotensin II results in angiotensin II type 1 receptor AT1R-mediated increase in myocardial TACE expression and activity, and membrane translocation of TACE |
734505 |
| 3.4.24.86 | anti-Ro/SSA autoantibody |
i.e. antinuclear autoantibodies in the blood directed against Ro/Sjögren's syndrome ribonucleoprotein A antigen. Adalimumab appears to be significantly more efficacious than Etanercept in preventing TACE activation caused by anti-Ro/SSA autoantibodies |
712137 |
| 3.4.24.86 | bortezomib |
stimulates ADAM17-catalyzed shedding of CD30, blocks bortezomib-stimulated sCD30 release from L540 cells with an IC50 of approximately 230 nM |
712920 |
| 3.4.24.86 | cytochalasin D |
- |
735270 |
| 3.4.24.86 | four and half LIM domain 2 protein |
four and half LIM domain 2 protein binds both ADAM-17 and the actin-based cytoskeletonand is involved in the regulation of ADAM-17 cellular localization and activity |
681031 |
| 3.4.24.86 | furin |
activates ADAM-17 |
681031 |
| 3.4.24.86 | glucose oxidase |
oxidative damage via glucose oxidase or hydrogen peroxide activates TACE and induces shedding of its targets, glycoprotein Ibalpha and glycoprotein V, in murine and human platelets. The TACE activation is independent of platelet activation. TACE activation induced by hydrogen peroxide is dependent on p38 mitogen-activated protein kinase signalling, whereas protein kinase C, phosphoinositide 3-kinase, and caspases are not involved. Inhibition of p38 cytoplasmic targets, phospholipase A2 and heat shock protein 27, does not prevent shedding, whereas blocking 12-lipoxygenase or Src kinase slightly inhibits TACE activation |
711689 |
| 3.4.24.86 | glutamate |
the shedding activity of the enzyme is increased during glutamate stimulation |
753220 |
| 3.4.24.86 | granulocyte-macrophage colony-stimulating factor |
granulocyte-macrophage colony-stimulating factor GM-CSF and interleukin-4 in combination potently up-regulate tumor necrosis factor-alpha coverting enzyme TACE and activity in monocytes, causing ectodomain shedding of M-CSF receptor |
711568 |
