EC Number   |
Activating Compound |
Reference |
|---|
   3.4.24.63 | more |
meprin beta is expressed as an inactive zymogen and requires proteolytic maturation by tryptic serine proteases, e.g. by matriptase-2 (MT2), but not by TMPRSS4 or pancreatic trypsin |
752709 |
| 3.4.24.63 | more |
the pro-enzyme is activated by proteoltyic cleavage of a propeptide |
753218 |
| 3.4.24.63 | Trypsin |
- |
31031, 31379, 650462, 652104, 652469 |
| 3.4.24.63 | Trypsin |
activation is accompanied by reduction in size of 8 kDa |
31380 |
| 3.4.24.63 | Trypsin |
activation, 5-20fold |
31024 |
| 3.4.24.63 | Trypsin |
by limited proteolysis |
31380 |
| 3.4.24.63 | Trypsin |
by limited proteolysis (2 h at 37°C, with tosyl-Phe chloromethyl ketone treated trypsin, in 20 mM Tris-HCl buffer, pH 7.5) |
31024, 31031 |
| 3.4.24.63 | Trypsin |
only with larger substrates (azocasein or insulin B), not smaller substrates |
31024, 31031 |
| 3.4.24.63 | Trypsin |
peptidase activity of expressed meprin B precursor is absolutely dependent on activation by trypsin |
31380 |
