EC Number   |
Activating Compound |
Reference |
|---|
   3.4.24.24 | 4-aminophenylmercuric acetate |
- |
651301 |
| 3.4.24.24 | aminophenylmercuric acetate |
- |
683842 |
| 3.4.24.24 | heparan sulfate |
essential for thrombin-mediated activation of pro-MMP-2 |
717813 |
| 3.4.24.24 | interleukin 1beta |
increases enzyme expression and activity in cardiac microvascular endothelial cells, involvement of PKC and/or MAPK signaling cascades, overview, the activation is inhibited by 52% by Gö6976, a PKC inhibitor, at 100 nM, while inhibitors SN50 and SP600125 have no effect on the activation |
683045 |
| 3.4.24.24 | membrane-type 1 matrix metalloproteinase |
activity in the extracellular environment is modulated by this activator |
653934 |
| 3.4.24.24 | MMP-14 |
MMP-14 activates MMP-2 during degeneration of invertebral disc, a major activation pathway of MMP-2 involves complex formation with MMP-14 and a tissue inhibitor of metalloproteinases-2, TIMP-2, overview |
683804 |
| 3.4.24.24 | more |
a complex formed by MT1-MMP, TIMP-2, and MMP-2 and located at the cell surface, is involved in MMP-2 activation, overview |
683846 |
| 3.4.24.24 | more |
activation of pro-MMP-2 by 4-aminophenylmercuric acetate |
683230 |
| 3.4.24.24 | more |
heparan sulfate is required for thrombin-mediated activation of pro-MMP-2 by binding to thrombin, presumably through conformational changes at the active site of the enzyme. Homodimerization of the enzyme enhances thrombin-mediated activation of pro-MMP-2. Enzyme residue Cys102 plays a role in inhibition of catalytic activity through a cysteine-zinc ion pairing, this pairing is disrupted by the intermolecular disulfide bond in the MMP-2 homodimer, resulting in enzyme activation. Disruption of the cysteine-zinc ion pairing by homodimerization of MMP-2 opens the active site, but it may accommodate only small peptide substrates. Thus, MMP-2 propeptide processing is a prerequisite to gain its proteolytic activity against large substrates, including gelatin |
734182 |
| 3.4.24.24 | more |
implantation of 9L glioma cells into brain increases the expression of MMP-2, overview |
683427 |
