EC Number   |
Activating Compound |
Reference |
|---|
   3.4.23.34 | 6-(4-chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime |
CITCO |
677830 |
| 3.4.23.34 | GTP |
activation, maintains enzyme in its active conformation at pH 5 and above |
30784 |
| 3.4.23.34 | IGCEERSFPNIIIIIG |
up to 260% activation of cythepsin E, KD value about 300 nM. Treatment of HeLa cells with cathepsin E and peptide results in decrease in cell viability, with a 1.5- and 3-fold increase in the level of apoptosis in comparison to cells treated with cathepsin E alone |
717685 |
| 3.4.23.34 | more |
mechanism of proenzyme activation |
30803 |
| 3.4.23.34 | more |
No activation of native enzyme by DTT |
30779 |
| 3.4.23.34 | more |
or 2-mercaptoethanol |
30779, 30784 |
| 3.4.23.34 | more |
screening for cathepsin E-activity-enhancing peptides functioning in the physiological pH range as potential cancer therapeutic candidates |
717685 |
| 3.4.23.34 | more |
the catalytically inactive proenzyme procathepsin E is rapidly converted to the active enzyme cathepsin E after brief treatment at pH 4 by autoproteolytic cleavage at Met36-Ile37 and Phe39-Thr40 to form two mature isozymic forms |
30793 |
| 3.4.23.34 | PGIKPPPCIIIIG |
up to 180% activation of cythepsin E |
717685 |
| 3.4.23.34 | Phenobarbital |
PB |
677830 |
