EC Number   |
Activating Compound |
Reference |
|---|
   3.4.22.63 | 2-(acetyloxy)benzoic acid 4-(nitrooxymethyl)-phenyl ester |
i.e. para-NO-ASA, activates proteolytic enzyme activation. The compund inhibits the proliferation and induces cell death in acute lymphoblastic leukemia cell lines and patient samples |
732763 |
| 3.4.22.63 | caspase-8 |
caspase-8 cleaves and activates caspase-10 directly |
709936 |
| 3.4.22.63 | FLICE-like inhibitory protein |
i.e. FLIPL, activation occurs independently of cleavage of either the caspase or FLIPL |
663939 |
| 3.4.22.63 | FLIPL protein |
heterodimerization with the long isoform of cFLIP, FLIPL, leads to activation of caspase-10. The heterodimer of caspase-10 with FLIPL still can cleave Bid and induce intrinsic apoptosis |
717282 |
| 3.4.22.63 | more |
caspase-10 is activated at the DISC, downstream of death-receptor signaling |
717282 |
| 3.4.22.63 | more |
in head and neck squamous cancer cell lines with low caspase-8 levels, Smac mimetics treatment induced caspase-10 activation |
731561 |
| 3.4.22.63 | more |
procaspase-10 is proteolytically activated to caspase-10, mechanism of activation and the role of the inter-subunit cleavage, overview. Caspase-10 follows the proximity-induced dimerization model for apical caspases. Chemically inducible dimerization fusions activate the wild-type but not the cleavage site mutant caspase-10 |
717252 |
| 3.4.22.63 | more |
proteolytic activation of caspase-10 is induced in apoptosis |
718261 |
| 3.4.22.63 | Sodium citrate |
activates the wild-type enzyme up to 500fold and the D297A mutant 100fold at up to 1.0 M, is inhibitory above probably due to precipitation |
717252 |
