EC Number   |
Activating Compound |
Reference |
|---|
   3.4.21.93 | 6-n-propyl-2-thiouracil |
produces hypothyroidism and induces a significant increase in the expression of PC1/3 in the paraventricular nucleus and lateral hypothalamus, but not ventromedial nucleus. Regulates colocalization of PC1/3 or PC2 in pro-thyrotropin-releasing hormone in the paraventricular nucleus, but not in lateral hypothalamus and ventromedial nucleus |
684334 |
| 3.4.21.93 | interleukin 6 |
- |
653223 |
| 3.4.21.93 | leptin |
leptin stimulation of the prohormone convertase 1/3 promoter is regulated by Nhlh2 and STAT3 in vitro. Nhlh2 binds to both E-box motifs on the prohormone convertase 1/3 promoter. The Nhlh2 and STAT3 transcription factors heterodimerize and interact on the prohormone convertase 1/3 promoter. Leptin-treated N2KO mice have significantly higher prohormone convertase 1/3 mRNA levels than ad libitum-fed N2KO mice |
700215 |
| 3.4.21.93 | Leukemia inhibitory factor |
- |
653223 |
| 3.4.21.93 | more |
hypothyroidism increases enzyme expression in hypothalamus and cerebral cortex |
669904 |
| 3.4.21.93 | more |
leptin stimulates the PC1 expression via STAT3 acting on the PC1 promoter |
669626 |
| 3.4.21.93 | morphine |
long-term morphine exposure (7 days) upregulates prohormone convertase 1/3 protein levels in the rat hypothalamus. The cyclic-AMP response element in the promoter of prohormone convertase 1/3 is required for morphine-induced regulation of prohormone convertase 1/3 |
700473 |
| 3.4.21.93 | Naltrexone |
stimulates prohormone convertase 1/3 promoter activity |
700473 |
| 3.4.21.93 | PC1/3 CT peptide |
increases PC1/3 activity at low concentrations (nanomol range). Interaction with the active site of PC1/3 does not result in the formation of a stable complex. Activation of PC1/3 by 5 nanomol CT-peptide is the same in the presence or absence of propeptide |
679776 |
| 3.4.21.93 | pioglitazone |
oral medication used in the treatment of type 2 diabetes, which decreases Pdcd4 levels, activates Akt, increases CgA and Sg II secretion and augments proprotein convertase 1/3 protein in Bon-1 cells. 7fold increase in proprotein convertase 1/3 mRNA in shPdcd4-transfected cells |
696517 |
