EC Number   |
Activating Compound |
Reference |
|---|
   3.4.21.73 | 1,3,8-trihydroxy-6-methylanthraquinone |
i.e. emodin, an active compound of aloe. Emodin increases the fibrinolytic activity of fibroblast cells in a dose-dependent manner, linked to increased uPA activity and uPA gene up-regulation. Emodin also induces up-regulation of uPA inhibitor PAI-1. Up-regulations are independent of emodin's effect on nuclear factor kappaB. The effect on the uPA system may be via generation of reactive oxygen species |
701373 |
| 3.4.21.73 | Ile-Ile |
an Ile-Ile or Ile-Val dipeptide can induce limited enzyme activity in the single-chain zymogen form of uPA or its K158A variant, which cannot be activated proteolytically |
707518 |
| 3.4.21.73 | Ile-Val |
an Ile-Ile or Ile-Val dipeptide can induce limited enzyme activity in the single-chain zymogen form of uPA or its K158A variant, which cannot be activated proteolytically |
707518 |
| 3.4.21.73 | integrin alpha v beta3 |
binds specifically to the enzyme and is required for plasminogen activation, overview |
684076 |
| 3.4.21.73 | interleukin beta |
significantly induces uPA expression and activity via protein kinase Calpha-dependent JNK1/2 and NIK cascades. Induction is inhibited by pretreatment with the inhibitors of JNK1/2, SP600125, of protein kinase C, Ro31-8220 and Go6976, or of nuclear factor kappaB, helenalin, and by transfection with dominant negative mutants of protein kinase C alpha, NIK, and IKKbeta, and siRNAs of JNK1/2 and p65 |
699131 |
| 3.4.21.73 | more |
binding of uPA to uPA receptor increases the catalytic efficiency by enhancing its activation by plasmin or other enzymes. uPAR promotes the invasive migration of hair follicles synergizing in manner dependent and independent of uPA during human prenatal morphogenesis |
707287 |
| 3.4.21.73 | more |
cytokeratin 8 ectoplasmic domain binding by a specific monoclonal antibody inhibits activation of plasminogen, the synthetic dodecapeptide corresponding to the epitope sequence, VKIALEVEIATY, binds uPA. The antibody increases adhesion of breast tumor cells to fibronectin |
709912 |
| 3.4.21.73 | more |
increase of uPA activity and expression by freezing/thawing process in porcine uterus endometrial epithelium cells |
708237 |
| 3.4.21.73 | more |
increased plasminogen activator activity in the lung by administering exogenous uPA or by using mice genetically deficient in the uPA inhibitor plasminogen activator inhibitor-1, PAI-1 |
707070 |
| 3.4.21.73 | more |
plasmin and urokinase-type plasminogen activator can activate each other through proteolytic cleavage |
717386 |
