EC Number |
Activating Compound |
Reference |
---|
3.1.3.43 | (1S)-1,5-anhydro-1-{[(1R,2R,3R,4S,5S,6S)-2,3,4,5-tetrahydroxy-6-methoxycyclohexyl]methyl}-D-galactitol |
i.e. C-INS-2-OH the deaminated analogue of C-INS-2 |
714447 |
3.1.3.43 | (1S)-2-amino-1,5-anhydro-2-deoxy-1-{[(1R,2R,3R,4S,5S,6S)-2,3,4,5-tetrahydroxy-6-methoxycyclohexyl]methyl}-D-galactitol |
i.e. C-INS-2, the C-glycoside of INS-2 |
714447 |
3.1.3.43 | 2-tetradecylglycidate |
together with insulin |
94896 |
3.1.3.43 | 4-O-beta-D-galactosaminyl-3-O-methyl-D-chiro-inositol |
i.e. INS-2, allosteric activation, docking study using crystal structure of the enzyme PDHP1, PDB ID 2PNQ, and mechanism, overview |
714447 |
3.1.3.43 | Ca2+ |
for isozyme PDP1c, simultaneous presence of Ca2+ and E2 component of substrate is required |
650417 |
3.1.3.43 | Ca2+ |
stimulates PDP1 at micromolar concentrations |
642164 |
3.1.3.43 | cysteine |
reverses glyoxylate inhibition |
94885 |
3.1.3.43 | Dichloroacetate |
together with insulin |
94896 |
3.1.3.43 | EGTA |
- |
94882 |
3.1.3.43 | inner lipoyl domain of dihydrolipoyl acetyltransferase |
component of substrate complex, structural requirements for binding and activation |
652240 |