EC Number   |
Activating Compound |
Reference |
|---|
   3.1.13.4 | 3'untranslated regions of RNA |
regulates RNase acitvity |
134095 |
| 3.1.13.4 | CH3COOK |
absolute required in absence of spermidine |
134096 |
| 3.1.13.4 | K+ |
allosteric activator of PARN and its truncated forms, optimal concentration is around 100 mM, with the increase of the K+ concentration, the enzyme reaches its Vmax at a much lower substrate concentration |
690777 |
| 3.1.13.4 | more |
Bic-C activates CCR4-dependent deadenylation of specific mRNAs during early oogenesis. Bic-C binds specific segments of the Bic-C 50 untranslated region and negatively regulates its own expression by binding directly to NOT3/5, a component of the CCR4 core deadenylase complex. CCR4-HA and NOT3/5 form an RNase-resistant complex with Bic-C |
679425 |
| 3.1.13.4 | more |
p21 3'-UTR triggers the action of PARN in the AGS cells |
749952 |
| 3.1.13.4 | more |
PARN interacts with the 7-methylguanosine cap, which enhances its deadenylation activity |
694441 |
| 3.1.13.4 | Pan2 protein |
required for poly(A)-binding in poly(A) cleavage |
134094 |
| 3.1.13.4 | poly(A)-binding protein PAB 1 |
PAB 1 required |
134093 |
| 3.1.13.4 | polyadenylate-binding protein |
or spermidine, required for activity of hPAN complex, cannot stimulate hPAN2 alone |
652522 |
| 3.1.13.4 | spermidine |
absolute required in absence of salt |
134096 |
