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3.1.1.64
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enzyme activity is dependent upon the presence of Rpe65
715473
3.1.1.64
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Rpe65 isomerase activity is strongly stimulated by addition of either 10% phosphatidylglycerol (10.5fold increase of activity) or 10% phosphatidylserine (8.5fold increase of activity) to liposomes containing the same major phospholipids as RPE membranes
715577
3.1.1.64
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the Cys-112 palmitylation site is essential for the membrane association and activity of RPE65
715501
3.1.1.64
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the lipid membrane structure is critical for RPE65 enzymatic activity
704711
3.1.1.64
MYO7A protein
the Usher 1B protein MYO7A is required for normal localization and function of the visual retinoid cycle enzyme RPE65. RPE65 normally undergoes a light-dependent translocation to become more concentrated in the central region of the RPE cells. This translocation requires MYO7A
715149
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