EC Number |
Activating Compound |
Reference |
---|
2.7.11.31 | (+)-simvastatin |
0.05 mM increases phosphorylation of AMPK at Thr172 by 2.6fold and acetyl-CoA carboxylase at Ser79 in BAEC. Ser428 phosphorylation of LKB1 is essential for statin-induced AMPK activation. Statin-induced AMPK activation in BAEC is independent of CaMKKbeta. Activation of AMPK by statin Is O2- or ONOO- dependent |
704431 |
2.7.11.31 | (+)-simvastatin |
in vivo administration of statin increases 3-nitrotyrosine and the phosphorylation of AMPK and acetyl-CoA carboxylase in wild-type mice but not in mice deficient in endothelial nitric-oxide synthase. PKC-zeta-dependent AMPK activation. In vivo transfection of PKC-zeta-specific small interfering RNA in mice significantly attenuates statin-enhanced phosphorylation of AMPK-Thr172, acetyl-CoA carboxylase-Ser79, and LKB1-Ser428 |
704431 |
2.7.11.31 | (+)-simvastatin |
LKB1 is required for statin-dependent AMPK activation. Transfection of LKB1-expressing plasmid is required for statin-induced AMPK activation in A-549 and HeLa S3 cell lines deficient in endogenous LKB1 |
704431 |
2.7.11.31 | (23E)-cucurbita-5,23,25-triene-3beta,7beta-diol |
CH10, triterpene from the stem of bitter melon Momordica charantia, leads to the activation of AMPK in cells, overcomes insulin resistance |
704122 |
2.7.11.31 | (5S)-3-[(13S)-13-hydroxy-14-(2-{[(2S)-2-hydroxydodecyl]oxy}ethoxy)tetradecyl]-5-methylfuran-2(5H)-one |
i.e. AA005 |
760351 |
2.7.11.31 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine |
activates AMPK, phosphorylation of AMPK-Thr172 is increased 2.8fold in the degenerated midbrain by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxication. AMPK activation is stimulated in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice |
702079 |
2.7.11.31 | 1-methyl-4-phenylpyridinium |
activates AMPK in SH-SY5Y cells. Increases phosphorylation level at Thr172 in the active site of AMPKalpha. AMPK is activated during the progression of cell death mediated by 1-methyl-4-pyridinium |
702079 |
2.7.11.31 | 2',3',5'-tri-O-acetyl-N-(3-hydroxyphenyl)adenosine |
EC50 of 0.3273 mM |
761360 |
2.7.11.31 | 2'-AMP |
- |
644957 |
2.7.11.31 | 2-deoxy-D-glucose |
- |
761034 |