EC Number   |
Activating Compound |
Reference |
|---|
   2.7.11.26 | 14-3-3 |
protein 14-3-3 recognises GSK-3 phosphorylated at Ser9, and the association of tau with this complex is believed to regulate its phosphorylation by GSK-3, since in human embryonic kidney cells, tau phosphorylation by GSK-3 is suppressed in the absence of 14-3-3, but GSK-3 is active and phosphorylates tau if 14-3-3 is present |
740530 |
| 2.7.11.26 | AICAR |
- |
741419 |
| 2.7.11.26 | AMP |
AMP binding induces a conformational change in the ? -subunit activation loop of the kinase that allows phosphorylation of the activating residue Thr172 by AMPK upstream kinases |
740531 |
| 2.7.11.26 | AMP |
AMP-activated protein kinase |
741419 |
| 2.7.11.26 | amyloid-beta 1-42 peptide |
0.005 mM |
693777 |
| 2.7.11.26 | AT7519 |
0.0005 mM AT7519 inhibits glycogen synthase kinase 3beta phosphorylation, AT7519 dephosphorylates GSK-3beta independent of inhibition of transcription |
706016 |
| 2.7.11.26 | beta-amyloid peptide |
- |
705453 |
| 2.7.11.26 | beta-amyloid peptide 1-42 |
0.01 mM, induces phosphorylation at Tyr216 activating GSK-3beta |
693729 |
| 2.7.11.26 | cAMP |
required for PKA activation |
662674 |
| 2.7.11.26 | cAMP |
required for PKA activity |
662302 |
