EC Number |
Activating Compound |
Reference |
---|
2.7.11.15 | (-)-Epinephrine |
requirement, agonist, alpha2-adrenergic receptor as substrate |
645000 |
2.7.11.15 | AlF4- |
enhances beta-ARK activity upon stimulation of heterotrimeric G proteins |
645026 |
2.7.11.15 | alpha2A-adrenergic receptor |
epinephrine-activated alpha2A-adrenergic receptor activates GRK2, interaction with GRK2 via the second and third intracellular loop of the receptor, determination of regions required for specific interaction utilizing recombinant GST-tagged wild-type and several mutant alpha2A ARs, residues R225, R226, R218, K320, R322, and K358 are important, overview |
662332 |
2.7.11.15 | arrestins |
arrestins modulate the enzyme activity having a regulatory role, regulation of arrestins, overview |
662911 |
2.7.11.15 | beta-arrestin |
required for phosphorylation activity and receptor substrate endocytosis |
662153 |
2.7.11.15 | beta-arrestin-2 |
forms a complex with GRK3 causing G protein-coupled receptor desensitization |
662131 |
2.7.11.15 | beta-arrestin-2 |
required, membrane protein |
661684 |
2.7.11.15 | beta-arrestin2 |
mediates GRK activity, forms a signaling complex with filamin and dopamine D3 receptor, interactions, overview |
662345 |
2.7.11.15 | beta2-adrenergic receptor |
interaction of beta-ARK 1 with the agonist-occupied receptor activates |
645028 |
2.7.11.15 | beta2-adrenergic receptor |
interaction of enzyme with human agonist-occupied receptor specifically and significantly enhances peptide phosphorylation, at lower concentrations, enhances both the affinity and catalytic efficiency for peptide phosphorylation |
645012 |