EC Number   |
Activating Compound |
Reference |
|---|
    2.4.2.30 | 3-amino-1-methyl-5H-pyrido[4,3-b]indole |
i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM |
675627 |
| 2.4.2.30 | 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide |
activates in presence of Mg2+, inhibits in absence of Mg2+ |
637997 |
| 2.4.2.30 | ATP |
5-10 mM, 20-30% stimulation |
637995 |
| 2.4.2.30 | Bmh1p |
a yeast homologue of the human FAS, acts as an activating ExoS cofactor, overview |
694800 |
| 2.4.2.30 | DNA |
absolute requirement |
637991, 637993 |
| 2.4.2.30 | DNA |
enzyme has an N-terminal binding domain |
638000 |
| 2.4.2.30 | DNA |
required |
637998 |
| 2.4.2.30 | DNA |
slightly increases activity |
725600 |
| 2.4.2.30 | DNA |
the enzyme is completely dependent on the presence of DNA containing single or double stranded breaks. Activation results in a decondensation of chromatin superstructure in vitro, which is caused mainly by hyper(ADP-ribosyl)ation of histone H1 |
637999 |
| 2.4.2.30 | FAS |
exoenzyme S absolutely requires a soluble eukaryotic protein, named FAS (Factor Activating exoenzyme E), in order to ADP-ribosylate all substrates. In the presence of FAS, exoenzyme S ADP-ribosylates several proteins in lysates of Pseudomonas aeruginosa. Purification and characterization of FAS |
662089 |
