EC Number   |
Activating Compound |
Reference |
|---|
   2.4.1.255 | Ataxin-10 |
Atx-10 increases OGT activity 2fold |
674603 |
| 2.4.1.255 | Ataxin-10 |
encoded by the SCA10 (spinocerebellar ataxia type 10) gene, interacts with O-GlcNAc transferase OGT in pancreatic beta cells |
657790 |
| 2.4.1.255 | CoCl2 |
stress treatment induces higher levels of OGT protein expression |
659361 |
| 2.4.1.255 | D-glucose |
immunoblot analysis of OGTase expression in RASM cells. The amount of the 78 kDa subunit is significantly increased in the high glucose, but no significant increase in the amount of the 110 kDa subunit is observed. OGTase expression and activity increased in the RASM cells cultured in the 20 mM glucose |
701898 |
| 2.4.1.255 | dithiothreitol |
increases the activity of wild type OGT |
659497 |
| 2.4.1.255 | ethanol |
stress treatment induces higher levels of OGT protein expression |
659361 |
| 2.4.1.255 | H2O2 |
stress treatment induces higher levels of OGT protein expression |
659361 |
| 2.4.1.255 | hyperglycemia |
increases O-GlcNAc levels in pancreatic beta cells, which appears to interfere with beta-cell function |
657790 |
| 2.4.1.255 | Insulin |
tyrosine phosphorylation of OGT increases significantly after a 10 min insulin treatment |
693100 |
| 2.4.1.255 | more |
beginning 12 h after treatment, glucose deprived human hepatocellular carcinoma (HepG2) cells demonstrate a 7.8fold increase in total O-GlcNAc modification compared with cells cultured in normal glucose (5 mM) |
704458 |
