EC Number   |
Activating Compound |
Reference |
|---|
    2.3.1.87 | 14-3-3 protein |
14-3-3zeta, interaction with the phosphorylated enzyme activates activity, binding analysis, overview |
702214 |
| 2.3.1.87 | 4beta-phorbol 12-myristate 13-acetate |
stimulates activity on a posttranscriptional level in a cAMP-independent manner |
659763 |
| 2.3.1.87 | 5-hydroxytryptophan |
activates, best at 0.1 mM |
719583 |
| 2.3.1.87 | forskolin |
decreases KM-value for tryptamine by 32% |
659760 |
| 2.3.1.87 | leptin |
increases enzyme activity only in fed fish not in fasted fish, independently of the seasons |
719583 |
| 2.3.1.87 | Melatonin |
activates, best at 0.1 mM |
719583 |
| 2.3.1.87 | more |
the enzyme is activated by Ser and Thr phosphorylations, e.g. AANAT Thr31 phosphorylation on its own can enhance catalytic efficiency up to 7fold |
702214 |
| 2.3.1.87 | N-acetylserotonin |
activates, best at 0.1 mM |
719583 |
| 2.3.1.87 | phorbol 12,13-dibutyrate |
stimulates activity on a posttranscriptional level |
659763 |
| 2.3.1.87 | phorbol 12-myristate 13-acetate |
decreases KM-value for tryptamine by 44% |
659760 |
