EC Number   |
Activating Compound |
Reference |
|---|
    2.1.1.13 | aquacob(III)alamin |
the addition of 0.05 mM aquacob(III)alamin to the crude extract results in an about 13fold increase in activity which is not greatly affected by the addition of cytochrome P450 reductase or reductase domain of neuronal nitric oxide synthase |
703638 |
| 2.1.1.13 | cadaverine |
up to 40% stimulation at 1 mm |
441207 |
| 2.1.1.13 | cyanocobalamin |
supports methyltransferase in extracts of animal tissues and Escherichia coli |
441196 |
| 2.1.1.13 | K+ |
at 67 mM 1.4 fold activity |
441179 |
| 2.1.1.13 | Li+ |
at 67 mM, 1.3fold activity |
441179 |
| 2.1.1.13 | methionine synthase reductase |
restores the activity of human methionine synthase through reductive methylation of methionine synthase-bound cob(II)alamin. Oxidized methionine synthase reductase does not reactivate methionine synthase, the presence of methionine synthase reductase along with AqCbl or MeCbl causes a dramatic increase in methionine synthase activity (7fold for AqCbl and 20fold for MeCbl) as compared to the cofactor alone |
703638 |
| 2.1.1.13 | methylcob(III)alamin |
the addition of 0.05 mM methylcob(III)alamin to the crude extract results in an about 6fold increase in activity which is not greatly affected by the addition of cytochrome P450 reductase or reductase domain of neuronal nitric oxide synthase |
703638 |
| 2.1.1.13 | Na+ |
at 67 mM 1.5 fold activity |
441179 |
| 2.1.1.13 | NADPH |
reactivation of methionine synthase is dependent on NADPH concentration in a hyperbolic manner with maximum activity at about 0.2 mM |
703638 |
| 2.1.1.13 | NH4+ |
at 67 mM 1.5 fold activity |
441179 |
