EC Number   |
Activating Compound |
Reference |
|---|
    1.2.1.3 | 2-mercaptoethanol |
100 mM, full activation |
348707 |
| 1.2.1.3 | 2-mercaptoethanol |
27% increased activity at 1 mM |
690591 |
| 1.2.1.3 | 2-mercaptoethanol |
about 140% activity at 5 mM |
722210 |
| 1.2.1.3 | 2-mercaptoethanol |
highest activity at 50 mM |
673291 |
| 1.2.1.3 | acetaldehyde |
substrate activation at elevated aldehyde concentrations |
348704 |
| 1.2.1.3 | Alda-1 |
acts as activator at high concentrations of aldehyde |
740442 |
| 1.2.1.3 | Alda-1 |
Alda-1 increases the affinity of ALDH2 for NAD+ which results in increased ALDH2 activity |
711691 |
| 1.2.1.3 | Alda-1 |
i.e. N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide, 0.01 mM Alda-1 increases acetaldehyde oxidation by wild type ALDH2 and the Asian variant E487K approximately 1.5 and 6fold, respectively. Alda-1 stimulates established ALDH2 activities by improving NAD+ binding but does not improve the nitroglycerin binding affinity of the Asian variant E487K |
712497 |
| 1.2.1.3 | ascorbate |
required |
719938, 729577 |
| 1.2.1.3 | beta-mercaptoethanol |
161.09% activity at 1 mM |
711536 |
