EC Number   |
Activating Compound |
Reference |
|---|
   1.2.1.104 | ADP |
stimulates |
655234 |
| 1.2.1.104 | AMP |
ascites tumour cells, 1 mM, about 2fold activation of pyruvate dehydrogenase |
348963 |
| 1.2.1.104 | cAMP |
ascites tumour cells |
348963 |
| 1.2.1.104 | dobutamine |
increases pyruvate dehydrogenase complex activity |
656612 |
| 1.2.1.104 | fatty acid transport protein 1 |
enhances mitochondrial pyruvate dehydrogenase activity |
700076 |
| 1.2.1.104 | GMP |
ascites tumour cells |
348963 |
| 1.2.1.104 | GTP |
1-10 mM, slight activation |
348986 |
| 1.2.1.104 | malate |
malate is stimulatory for the mitochondrial pyruvate dehydrogenase complex, but not for barley chloroplast pyruvate dehydrogenase complex. The stimulation is saturated below 1 mM malate and is related to the partially activated complex, which activity increases in the presence of malate by about twofold. Malate also reverses the reduction of pyruvate dehydrogenase complex activity in the presence of glycine |
759744 |
| 1.2.1.104 | more |
enzyme complex activity is increased with high workload and energy expenditure in the myocardium |
656612 |
| 1.2.1.104 | more |
no activation with AMP in adrenal medulla |
348963 |
