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EC Number
Activating Compound
Commentary
Reference
1.14.16.4
14-3-3 protein
activates the phosphorylated TPH2
684993
1.14.16.4
2-mercaptoethanol
30 mM, 79.3% activity compared to activation with dithiothreitol
671723
1.14.16.4
2-mercaptoethanol
essential for activation
438657
1.14.16.4
2-mercaptoethylamine
30 mM, 93.8% activity compared to activation with dithiothreitol
671723
1.14.16.4
2-mercaptopropionate
30 mM, 11.7% activity compared to activation with dithiothreitol
671723
1.14.16.4
3-Mercaptopropionate
30 mM, 22% activity compared to activation with dithiothreitol
671723
1.14.16.4
CaCl2
1 mM, 7% activation
438671
1.14.16.4
dithiothreitol
-
438657
1.14.16.4
dithiothreitol
10 mM
671723
1.14.16.4
dithiothreitol
or other sulfhydryl reagents like 2-mercaptoethanol and L-cysteine are essential for activation, 5fold increase in activity
438658
,
438661
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