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EC Number
Activating Compound
Commentary
Reference
1.14.14.25
cholesterol 3-sulfate
i.e. CH-35
689814
1.14.14.25
efavirenz
EFV, activates the enzyme pharmacologically as a potential target for Alzheimers disease
736502
1.14.14.25
lovastatin
induces and activates the enzyme, acts neuroprotectively in hippocampus after kainate injury, overview
675535
1.14.14.25
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cortical injury increases cholesterol 24S hydroxylase levels in the rat brain, overview
688555
1.14.14.25
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pharmaceuticals activate CYP46A1 allosterically through binding to the site on the cytosolic protein surface, which is different from the enzyme active site facing the membrane
736502
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