EC Number |
Activating Compound |
Reference |
---|
1.14.11.65 | ascorbate |
- |
744861, 745951, 753164 |
1.14.11.65 | ascorbate |
required |
746537 |
1.14.11.65 | fisetin |
fisetin induces DNA damage via critical transcription factor RFXAP/KDM4A-dependent histone H3K36 demethylation, thus causing inhibition of proliferation in pancreatic adenocarcinoma (PDAC). Fisetin inhibits cell proliferation and induces DNA damage and S-phase arrest in PDAC. Expression of RFXAP and other DNA-damage response genes is upregulated by fisetin. RFXAP targets KDM4A. Overexpression of RFXAP upregulates KDM4A and attenuates methylation of H3K36, impairing DNA repair and enhancing the DNA damage induced by fisetin |
764436 |
1.14.11.65 | HP1a |
Suv(Var)3-9/KMT1 interacts with HP1 that binds [histone H3]-N6,N6-trimethyl-L-lysine9 |
701212 |
1.14.11.65 | more |
interleukin-1beta enhances recruitment of LSD1 to mPGES-1 promoter |
744188 |
1.14.11.65 | more |
local demethylation of H3K9me2 is triggered by recruitment of liganded estrogen receptor ERalpha to chromatin |
701223 |
1.14.11.65 | tetrahydrofolate |
binding kinetic analysis of folate derivatives, e.g. folates bound to glutamates, the (6R,S) form of the natural pentaglutamate form of tetrahydrofolate bound with the highest affinity to full-length LSD1, binding of different forms of folate to LSD1, and binding structures, overview |
752751 |