EC Number   |
Activating Compound |
Reference |
|---|
   3.4.22.64 | cholera toxin B |
a caspase-11-activating toxin |
731613 |
| 3.4.22.64 | lipopolysaccharide |
activation by intracellular LPS leading to caspase-11 oligomerizes into protein complexes and enzymatic cleavage of gasdermin D (GSDMD) into pore-forming peptides. Recognition of LPS by caspase-11 requires guanylate-binding proteins (GBPs). LPS-caspase-11 interaction in the intestinal epithelium is not observed when GBPchr3 KO (knockout) mice, which lack GBP1, 2, 3, 5, and 7, are used as HSCT recipients |
774568 |
| 3.4.22.64 | lipopolysaccharide |
LPS from Escherichia coli strain 0111:B4 |
773810 |
| 3.4.22.64 | lipopolysaccharide |
LPS, activates caspase-11. Caspase-11 can be activated by binding to internalized LPS |
771444 |
| 3.4.22.64 | lipopolysaccharide |
LPS, activates the enzyme |
771415 |
| 3.4.22.64 | lipopolysaccharides |
the non-canonical inflammatory pathway-induced pyroptosis is induced by lipopolysaccharide (LPS) on the surface of gram-negative bacteria. This activates caspase-11. LPS to directly enter the cell and activate caspase-11 |
770138 |
| 3.4.22.64 | LPS |
caspase-11 is an essential endogenous receptor for LPS, which binds to the CARD domain of caspase-11 through its lipid A tail moiety to regulate caspase-11 activation, overview |
772221 |
| 3.4.22.64 | LPS |
cytosolic LPS induces Casp11 speck formation. Binding of bacterial LPS to its cytosolic sensor, caspase-11 (Casp11), promotes Casp11 aggregation within a high-molecular-weight complex and activation of caspase-11 catalytic activity |
770759 |
| 3.4.22.64 | more |
activation through dimerization. Signaling pathways involved in caspase-11 activation, overview |
731613 |
| 3.4.22.64 | more |
Bacterial infection triggers caspase-11 activation , and intracellular lipopolysaccharide triggers caspase-11 activation, Toll-like receptor 4 is dispensable for caspase-11 triggering by cytoplasmic lipopolysaccharide, mechanism, detailed overview |
731905 |
