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EC Number
Activating Compound
Commentary
Reference
complement factor B
the enzyme factor D is activated by its substrate factor B through interactions outside the active site. The substrate-binding, or exosite, region displays a well defined and rigid conformation
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A direct repeat element located in the proximal human vegf-D gene promoter, consisting of a consensus half-site (AGGTCA) at -125/-119 and a degenerated direct repeat half-site (ATGTTA) at -99/-94 is sufficient and necessary for vegf-D transcription. The vegf-D direct repeat element is bound and activated by the orphan receptors hepatocyte nuclear factor 4A and chicken ovalbumin upstream promoter transcription factor 1 and 2 as well as transcriptional coactivators glucocorticoid receptor interacting protein 1 and cyclic AMP-responsive element binding protein-binding protein to drive vegf-D gene transcription. Histone deacetylase inhibition by trichostatin A leads to accumulation of acetylated histones H3/H4 at the vegf-D promoter, up-regulation of vegf-D mRNA levels, and transactivation of vegf-D promoter reporter gene constructs in cancer cell lines
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adenovirus-mediated expression of VEGF-D is significantly higher than that of baculovirus
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