EC Number |
Activating Compound |
Reference |
---|
2.7.7.6 | spermidine |
optimal activity at pH 8.5 is obtained in presence of 18 mM MgCl2, 200 mM KCl, 1 mM thermine and 1 mM spermidine |
643562 |
2.7.7.6 | thermine |
optimal activity at pH 8.5 is obtained in presence of 18 mM MgCl2, 200 mM KCl, 1 mM thermine and 1 mM spermidine |
643562 |
2.7.7.6 | more |
Pol III initiates and reinitiates transcription in the absence or presence of transcription factors, during the first transcription cycle transcription factors IIIB and IIIC mainly contribute to the selectivity and not to the rate of Pol III association to the template, while their stable association with the promoter in subsequent cycles strongly contributes to the high rate of transcription reinitiation by Pol III |
691700 |
2.7.7.6 | RNase P |
required for Pol I and Pol III required |
694828 |
2.7.7.6 | TFIIS |
an RNA cleavage stimulatory factor TFIIS. TFIIS can rescue an arrested polymerase by creating a new RNA 3' end at the active site from which transcription can resume, mechanism, overview |
701466 |
2.7.7.6 | CK2 |
is associated with Pol I, the initiation-competent subclass of Pol I, CK2 phosphorylates a number of proteins involved in Pol I transcription and pre-rRNA processing, including UBF, TIF-IA, SL1/TIF-IB, topoisomerase IIa, nucleolin, and nucleophosmin, overview |
701717 |
2.7.7.6 | more |
The activity of basal Pol I factors is regulated by posttranslational modifications |
701717 |
2.7.7.6 | PAF53 |
a 53-kDa protein that is associated with Pol I, recruitment of Pol I to the pre-initiation complex requires the interaction of UBF with SL1/TIF-IB and with PAF53 |
701717 |
2.7.7.6 | TAFI protein |
performs important tasks in transcription complex assembly, mediating specific interactions between the rDNA promoter and Pol I, thereby recruiting Pol I, together with a collection of Pol I-associated factors, to rDNA |
701717 |
2.7.7.6 | TIF-IB/SL 1 |
Pol I promoter specificity is conferred by TIF-IB/SL1, a protein complex containing the TATA binding protein and five TATA binding protein-associated factors, including TAFI110/95, TAFI68, TAFI48, TAFI35, and TAFI12 |
701717 |