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EC Number
Activating Compound
Commentary
Reference
2.7.4.14
2-mercaptoethanol
activates
645143
2.7.4.14
2-mercaptoethanol
at 5 mM: reduction in molecular weight from approximately 53000 Da to 17000 Da. This low molecular weight form is partially active in the presence of 2-mercaptoethanol. In absence of 2-mercaptoethanol the low molecular weight form is inactive. At 50 mM: full reactivation of the CMP(ATP) kinase activity followed by dCMP(ATP) and CMP(dCTP)
645142
2.7.4.14
dithiothreitol
1 mM, activates
645149
2.7.4.14
dithiothreitol
activates
645143
,
645149
2.7.4.14
doxorubicin
binding of doxorubicin to the enzyme (CMPK1) activates the phosphorylation of CMP, dCMP, and UMP. Doxorubicin might bind to the nonactive site of CMPK1 and regulate its activity with magnesium
762474
2.7.4.14
glutathione
activates
645143
2.7.4.14
L-Cys
activates
645143
2.7.4.14
NADPH
NADPH-dependent activation system is composed of at least two protein factors: one is heat-stable and the other is indistinguishable from NADPH-dependent disulfide reductase
645144
2.7.4.14
reduced DL-alpha-lipoic acid
activates
645143
2.7.4.14
thioredoxin
activates
645142
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